Xxxix No . 9 the Synergisim of Nucleoside Antibiotics Combined with Guanine 7 - N - Oxide against a Rhabdovirus , Infect 10 Us Hematopoietic Necrosis Virus ( Ihnv ) †

نویسنده

  • NELsoN J. LEoNARD
چکیده

Guanine 7一N-oxide was shown to have synergistic activity in combillation with neplanocin Aagainst a rhabdovirus, infectious hematopoietic necrosis virus (IHNV), as reported previ ously. We examined further the antiviral activity of guanine 7-N-oxide ill comblnation with other nucleoside antibiotics against IHNV. Synergism was seen between guanille 7-N-oxide and D-eritadenine or cordycepin.16s considered that compounds inhibiting RNA methylation show synergism with guanine 7-N-oxide.

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تاریخ انتشار 2006